Early Beginnings.....

     In 1558, Swiss naturalist Konrad Gesner used lenses to study the shells of snails.
     George Huefnagel of Frankfort claimed to have invented the microscope, publishing several engravings of insects in 1592, perhaps drawn with the aid of a microscope.
     In 1595, Jansen invented the compound microscope.
     Kepler, around 1610 in his treatise "Dioptrice," showed with his theory of geometrical optics that two lenses could be arranged to make nearby objects appear larger.
     Galileo helped make the microscope popular in the first half of the 17th century.
     The Englishman Robert Hook made elegant compound microscopes, that consisted of two pairs of lenses in a thick cylindrical housing.  Multiple knobs and screws on the housing allowed for fine adjustment and focus.  Hook was a meticulous scientist, observing various organs of insects, feathers, molds, plant tissues, and the structure of cork.  To Hook, the compartmentalized configuration in the structure of cork looked like compartments in which monks lived, and he called them "cells."  Hook published his many observations in his landmark 1665 work, "Micrographia."

"Robert Hooke: Life History, drawing of cork"

"Hooke's compound microscope"


     Jan Swammerdam (1637-1680) : A Dutch naturalist who used compound microscopes to categorize and dissect more than 3000 species of insects.  He is known as the world's first modern entomologist.
     Marcello Malpighi (1628-1694) : An Italian physician who used the microscope to examine lung tissue.  In the process, he discovered capillaries, confirming Harvey's theory of blood circulation.