Available Technologies (through the UA Office of Technology Transfer)

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Updated: 14 hours 29 min ago

Noninvasive Real-Time Patient-Specific Assessment of Stroke Severity

Tue, 2019-01-15 18:56
ua18-140 - Tech ID: 18-140   Title: Noninvasive Real-Time Patient-Specific Assessment of Stroke Severity Invention: The proposed technology is a sensor and software that incorporates patient-specific information and machine learning algorithms to produce a highly biofidelic predictor for tissue infarction after a stroke or transient ischemic attack. Background: Current technology for post stroke and transient ischemic attack is invasive and exposes patients to a high amount of radiation and lack accuracy. The proposed technology focuses on a system that produces an accurate assessment of a patient’s brain tissue post stroke. The system incorporates CTA images to provide real-time estimates stroke severity and cerebral blood flow.   Applications: • Medical device in hospitals to assess patient’s stroke or transient ischemic attack severity   Advantages: • High-resolution • Efficient • Low cost • Accurate • Noninvasive • Real-time cerebral blood flow   Licensing Manager: Bob Sleeper RobertS@tla.arizona.edu 520-626-4604

Targeted Therapeutic Delivery in Nonalcoholic Steatohepatitis (Nash)

Tue, 2019-01-15 18:56
ua18-112 - Title: Targeted Therapeutic Delivery in Nonalcoholic Steatohepatitis (NASH)   Invention: This technology utilizes selective expression of a cell receptor as a novel diagnostic and pharmacologic pathway in assessing and treating NASH.   Background: Non-acoholic Steatohepatitis (NASH), a type of fatty liver disease, is characterized by large fat deposits within liver tissue that facilitate fibrotic liver damage and inflammation. With estimated 3-12% of adults in the US having NASH, the prevalence and incidence rates of NASH are on the rise. Because not all causes for NASH are known, few treatment options exist. This technology contains information that is vital to the development of new therapeutic medications with high selectivity for patients with NASH. In addition, this technology contains the methodologies to develop diagnostic imaging protocols and diagnostic testing protocols for NASH detection and characterization.   Applications:   Licensing Manager:   Licensing Manager: Kaitlyn Norman-Powers        KaitlynN@tla.arizona.edu (520) 621-9907

Kinematically Engaged Yoke System

Mon, 2018-12-31 12:30
ua19-024 - Title:  Kinematically Engaged Yoke System   Invention:  Researchers at the University of Arizona have designed a paradigm-shifting space telescope technology.  The technology produces ultra-lightweight, transmissive lenses that are fabricated economically in segments.  The novel aspects of the technology facilitate quick assembly with very high precision alignment..   Background:  Improvements in space telescope technology are needed. For example, mirror systems may be heavy, costly, and may comprise transmission loss and reduction in light throughput. Also, segmented mirror system has very sensitive alignment and assembly tolerance, which increases the overall system complexity and budget.   Advantages:  *  quick assembly *  excellent alignment among segments *  lightweight *  very large aperture   Applications: *  space-based astronomy *  ground-based astronomy   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-024

Methods and Apparatus for Confocal Endoscopes

Mon, 2018-12-31 12:30
ua19-046 - Title: Methods and Apparatus for Confocal Endoscopes   Invention: Researchers at the University of Arizona have designed a hyperchromatic objective lens system for use in chromatic confocal microscopy.  Advantageously, the use of fewer components for the objective lens may reduce the cost, size, and complexity of the microscopy optics, which can make the chromatic confocal microscope system suitable for endoscopic devices.   Background: In confocal microscopes and confocal endoscopes, multiple images (e.g., en face images) can be acquired at different imaging depths while axially translating the confocal microscope relative to the specimen. This approach of conducting mechanical axial scanning, however, can have difficulties such as in confocal endoscopic imaging of human internal organs, since 1) implementing a precision translation mechanism is challenging in a small endoscope and 2) tissue movement can hamper accurate placement of the imaging depth. Chromatic confocal microscopy can use longitudinal chromatic aberration of the microscope optics to generate different focal planes for different wavelengths and generate cross-sectional confocal images of the specimen without conducting axial scanning of the objective lens.   Applications: • Confocal Endoscopy • Confocal Laser Endoscopy • Optical biopsies   Advantages: • Fewer parts • Smaller size • Less expensive • Less complex   Contact:  Amy Phillips Amyp@tla.arizona.edu Refer to case number UA19-046

Using Machine Learning to Create High-Efficiency Optical Design Tools

Mon, 2018-12-31 12:30
ua19-048 - Title:  Using Machine Learning to Create High-Efficiency Optical Design Tools   Invention:  Researchers at the University of Arizona have developed systems and techniques that enable a determination of an estimated mapping from the design parameter space to the performance parameter space in real time.   Background:  Optical lens design is the process of designing a lens to meet a set of performance requirements and constraints.  The design process is computationally intensive.  One problem in optical system design is that, although finding a mapping from the design parameter space to the performance parameter space is easy (taking only a single ray trace), given a desired set of performance characteristics, it is extremely complicated to determine the corresponding design parameters.   Advantages: * saves time * increases functionality of design software   Applications: * optical design software   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-048

Trapezoidal Shim for Segmented Optics Assembly

Mon, 2018-12-31 12:30
ua19-053 - Title:  Trapezoidal Shim for Segmented Optics Assembly   Invention:  Researchers at the University of Arizona have designed a paradigm-shifting space telescope technology.  The technology produces ultra-lightweight, transmissive lenses that are fabricated economically in segments.  The novel aspects of the technology facilitate quick assembly with very high precision alignment..   Background:  Improvements in space telescope technology are needed. For example, mirror systems may be heavy, costly, and may comprise transmission loss and reduction in light throughput. Also, segmented mirror system has very sensitive alignment and assembly tolerance, which increases the overall system complexity and budget.   Advantages:  *  quick assembly *  excellent alignment among segments *  lightweight *  very large aperture   Applications: *  space-based astronomy *  ground-based astronomy   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-053

Fast Gamma-Ray Interaction-Position Estimation

Mon, 2018-12-31 12:30
ua19-056 - Title:  Fast gamma-ray interaction-position estimation   Invention:  Researchers at the University of Arizona have developed systems and methods for estimating gamma ray positions that are faster, more accurate, and more computationally and memory-use efficient than known systems and methods used in the medical imaging field.     Background:  Scintillator-based detectors have been extensively used in both clinical and pre-clinical SPECT and PET scanners, due to their relatively low cost, high gamma-ray stopping power and fast timing [1]. Position-estimation algorithms or decoding methods are applied for gamma-ray interaction position localization with signals induced by scintillation photons on light sensors (PMTs, SiPMs, etc.). Many gamma-ray position estimation/decoding algorithms based on reference datasets have been proposed because they provide better positioning capability for gamma-ray interactions especially at detector edges and corners, and also filter out events that Compton scatter and deposit energy in multiple positions in the detector.  But reference-data-based methods need detector calibration to acquire their reference datasets, and the position estimation speed remains relatively slow due to the excessive computations required. Thus, the current need for position estimation is for both high levels of accuracy and efficiency.   Advantages: *  Faster *  More accurate position estimation *  Can be used with detectors with complicated mean-detector-response functions .   Applications: *  gamma ray imaging *  other medical imaging   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-056

Chalcogenide Hybrid Inorganic/Organic Polymers (Chips) Using Cyclic Olefinic Comonomers

Fri, 2018-12-21 11:33
ua19-075 - Title: Novel Polymers for Mid- and Long-Wave Infrared Imaging   Invention:  New polymer compositions that are transmissive for mid-wave infrared (3-5 microns) and long-wave infrared (8-12 microns) sensing and imaging.   Background: Infrared imaging conventionally uses expensive inorganic transmissive materials for lenses, such as chalcogenide glass and amorphous germanium, which require cutting and polishing.  This inventive polymer-based transmissive medium can be formed using scalable, inexpensive polymer production processes.   Applications: • LiDAR • Electronics • Optics   Advantages: • Inexpensive • Useful for mid- or long-wave IR applications Licensing Manager: Laura Silva LauraS@tla.arizona.edu 520-626-1557

Silicone Waveguide for Solar Applications With High Concentration

Wed, 2018-12-19 14:14
ua19-041 - Title: Silicone waveguide for solar applications with high concentration   Invention: Researchers at the University of Arizona have developed low-cost silicone-based optical light guides configured to concentrate sunlight onto photovoltaic cells with above 90% optical efficiency.  The fabrication is inexpensive, affords flexibility, and ease of assembly. Integration of multiple light guides enjoys relaxed alignment tolerances compared to glass.   Background: In solar applications, waveguides and/or lightguides are often used to redirect and spatially concentrate the sunlight onto photovoltaic cell (PV-cells). Glass lightguides can be utilized, but can be expensive and complex to fabricate, expecially when small geometrical features are required.  Assembly of a plurality of glass-based lightguides into a full system is also tedious and complicated.  Polymeric materials can address some of these issues, are well known to have a relatively high level of absorbance in the UV and NIR regions of the solar spectrum, when high transmittance is needed.   Applications: • Solar Applications   Advantages: • Transparent in the 300-1700nm region • UV resistant • Design flexibility • Reduces the cost of manufacturing/mass production • High transmission throughout the solar spectrum • Improved tolerance to misalignment while maintaining over 90% optical efficiency   Licensing Manager: Amy Phillips AmyP@tla.arizona.edu Refer to case number UA19-041  

Silicone Aspherical Lens Array for Concentrating Solar Applications

Wed, 2018-12-19 14:14
ua19-040 - Invention:  Researchers at the University of Arizona have designed a silicone based linear lens array capable of high efficiency and low cost. The lens design produces a higher concentration line than traditional lenses, reduces optical aberrations, and facilitates fabrication. The design also creates greater rigidity, reduces Fresnel reflection loss, and eliminates refractive index changes among elements within a complex lens. Background:  Current sunlight-concentrating optical elements and/or systems suffer from various deficiencies.  For example, mirror-based concentrators require robust and costly mechanical design due to their weight, which increases installation costs.  Optical cylindrical lenses made of glass - while arguably being suited for solar applications requiring small linear light-concentration performance - are difficult and costly to manufacture for mass production. Existing polymer lenses have high absorbance in the UV and NIR portions of the solar spectrum, which drastically limits their use in broad-band solar energy concentrators.   Applications: • Solar concentrators   Advantages: • High transmission efficiency in the solar spectrum • Low manufacturing, assembly, and usage costs • Provides for lightweight optics • Increased rigidity of lens array system • Allows for deposition of anti-reflection coating • Provides for optical bonding means between polymer lens and glass without adhesive • Greater clarity • Excellent chemical resistance • Excellent thermos-mechanical stability • Cost effective fabrication • Higher transmittance of light • Reduced photo degradation • Reduced thermal deformation • Less maintenance and light weight Licensing Manager:  Amy Phillips AmyP@tla.arizona.edu Refer to case number UA19-040

Sucrose-Derived Scaffold for Gd MRI Contrast Agent and Method for Use in Colon Cancer Screening

Wed, 2018-12-19 14:14
ua19-099 - Title: A Novel Gd-Sucrose Scaffold for Oral Administration in MR-Colonography   Invention: This invention is a targeted molecular imaging agent to be used in conjunction with MRI or CT. It is designed especially for the early and specific detection of colorectal cancer. The formulation of this novel contrast agent allows for non-invasive imaging of the entire colon, with excellent soft-tissue contrast.   Background: The key to high survival rates for colorectal cancer is the early detection and staging of the disease. Current methods lack high and specific visualization, or are invasive, which leads to patient noncompliance. Over the last decade, MRI used for staging of rectal cancer has been reported to up or down stage rectal cancer by 20%. New imaging agents therefore have an important role to play in improving patient outcomes.   Applications: • Differentiation of benign and malignant disease • Evaluation of response to chemotherapy/radiation therapy • Selection of a patient-specific cancer therapy   Advantages: • Can detect small or flat polyps • Enhanced spatial resolution • Noninvasive (could improve patient noncompliance)   Licensing Manager: Laura Silva LauraS@tla.arizona.edu 520-626-1557

Hybrid Pyramid-Shack-Hartmann Wavefront Sensor

Mon, 2018-12-17 15:04
ua19-002 - Title: Hybrid Pyramid-Shack-Hartmann Wavefront Sensor   Invention: This invention describes a novel design for a wavefront sensor that provides high sensitivity, wide dynamic range, and linearity.     Background:  Wavefront sensors are at the forefront of the adaptive optics field. An essential element of any adaptive optics system is having an effective wavefront sensor that can identify any aberrations in the optical data collected, but current wavefront sensors have a tradeoff between their properties and none yet allow for all of the ideal properties to be reached.   Applications:   Advantages:   Licensing Manager: Amy Phillips AmyP@tla.arizona.edu

Induction Heating for Forming High-Precision Metal Panels

Mon, 2018-12-17 15:04
ua19-008 - Title: Induction Heating for Forming High-Precision Metal Panels   Invention: Researchers at the University of Arizona have developed a method for slumping metals and doped glasses that provides controlled heating across the entire piece, allowing for the formation of optical quality objects.  The process is about 10 times faster than the conventional kiln method and requires much less energy.   Background: Slumping is a method of forming either glass or metal to the shape of a particular mold. This is typically done in a kiln, but unfortunately, this does not eliminate the risk of uneven heating in a material, which can lead to  imperfect slumping.  In addition, there are intense energy requirements due to the high temperatures needed in the kiln, and the length of time it takes to get uniform heating throughout the material.   Applications:   Advantages:   Licensing Manager: Amy Phillips AmyP@tla.arizona.edu

Polaritonic Phase Transition Computing Architecture

Mon, 2018-12-17 15:04
ua19-010 - Title: Polaritonic Phase Transition Computing Architecture   Invention: This invention describes a novel means of using polaritonic switches to enable more efficient optical computing architecture, such as basic logic gates. This invention overcomes current limitations in electronic circuits, such as interconnection delays and heat generation and increases data-bandwidth capabilities. This would enable more effective computing architecture, better telecommunication systems and a multitude of other desirable results in computer system design.   Background: Optical computing has remained an area of interest since the first constraints of silicon-based architecture were recognized. Typically constrained to areas of intensive research, the technology is on the cusp of an increase in interest and development, especially with current pressures for more computing power in areas like artificial intelligence.   Applications:   Advantages: Licensing Manager:  Amy Phillips AmyP@tla.arizona.edu Refer to case number UA19-010

Mems-Based Hybrid Beam Steering for LIDAR

Mon, 2018-12-17 15:04
ua19-013 - Title: MEMS-based Hybrid Beam Steering for LiDAR   Invention: Researchers at the University of Arizona have developed an advanced LiDAR technology that combines MEMS and DMD technologies in a novel way.  The system is more compact with a larger field of view, and can track objects at a further distance, or at a closer range with finer resolution for applications in factories and warehouses.   Background: Currently available LiDAR sensing for autonomous vehicles space suffer from too narrow a field of view, thus requiring mechanical scanning, as well as being bulky and expensive.  Smaller systems have not been able to achieve the distance requirements needed for autonomous vehicles.  There is a need in the art for LiDAR systems to become more compact, have larger fields of view, and detect objects at greater distances.   Applications:   Advantages:   Licensing Manager: Amy Phillips AmyP@tla.arizona.edu

Fabrication of Polymer Waveguide Interconnect Between Chips With a Gap/Step Using Flexible Polymer Dry Film Resist for Photonic Integrated Circuits (Pics)

Thu, 2018-11-29 17:43
ua18-107 - Title: Fabrication Of Polymer Waveguide Interconnect Between Chips With A Gap And/Or Step   Invention: This technology describes a new method to form a stable physical barrier between chips within a photonic integrated circuit (PIC), utilizing polymer dry film negative resist. The technique enables the  fabrication of polymer waveguide interconnects.   Background: The current standard of applying polymer dry film resists works well for a single chip However, when there is a gap or step between two chips, the resist can break at the gap/step upon removing the backing.   Applications:   Advantages:   Licensing Manager: Amy Phillips AmyP@tla.arizona.edu

Integrated Optical I/O Port Combiner

Thu, 2018-11-29 17:43
ua18-206 - Title:  Integrated Optical I/O Port Combiner   Invention:  Researchers at the University of Arizona have designed a polarization splitter rotator (PSR) that enables use of a single optical port for input and output signals simultaneously.  This allows the output ports to connect to a wider variety of components and frees up other I/O ports for additional functions, or reduces the number of optical I/O ports required on a photonic integrated circuit.   Background:  Polarization splitter rotators (PSR) are used to separate the different polarization states of a beam of light entering the input port of the rotator, into different output ports on a photonic integrated circuit (PIC). These are generally used in one direction only, and lack efficiency.   Advantages:  *  Reduces the required number of optical I/O ports (or roughly doubles the number of available I/O ports) *  Increases the utilization of the capacity available on the chip *  Eliminates cross-talk and Bragg grating effect   Applications: *  Photonic integrated circuits (PICs) *  Telecommunications   Contact:  Amy Phillips aphillips@optics.arizona.edu Refer to case number UA18-206

Laser Beam for External Position Control and Traffic Management of On-Orbit Satellites

Fri, 2018-10-26 17:42
ua19-036 - Title: Laser Beam for External Position Control and Traffic Management of On-Orbit Satellites   Invention: This invention is a satellite control system. The system consists of a customized “smart skin” containing solar panels, power and control circuitry, and an embedded secondary propulsion system. A laser is used from a ground station or another spacecraft and is beamed towards the satellite. The satellite has onboard photovoltaics that act as a wake-up laser receiver. This approach enables a laser ground station or a spacecraft to broadcast commands to the spacecraft in times of emergency that would trigger operation of the secondary propulsion system to perform impulse maneuvers, altitude control maneuvers, and corrections.   Background: This technology offers several benefits over existing techniques, such as low initial investment, low power usage, high bandwidth, and high security. The “over-congestion” of key satellite orbits greatly decreases their utility, as collisions become far more likely. Adding an actuated reflector to the spacecraft will enable laser ranging and two-way communication between ground station and the spacecraft, in a secure manner not currently available to RF communication systems. There is a need to develop secondary and backup systems to effectively move these satellites and perform traffic management of derelict satellites so that collision risks are minimized or eliminated.   Applications: • On-Orbit Satellites • Optical Communication Technology • Small Electronic Devices • Government & Military • Commercial & Private Entities   Advantages: • Low cost • Long-distance • Increased data • High bandwidth • Secure Transmission   Licensing Manager: Bob Sleeper RobertS@tla.arizona.edu 520-626-4604

Novel Polymers for Mid-and Long-Wave Infrared Imaging

Wed, 2018-10-03 17:42
ua19-032 - Title: Novel Polymers for Mid- and Long-Wave Infrared Imaging   Invention:  New polymer compositions that are transmissive for mid-wave infrared (3-5 microns) and long-wave infrared (8-12 microns) sensing and imaging.   Background: Infrared imaging conventionally uses expensive inorganic transmissive materials for lenses, such as chalcogenide glass and amorphous germanium, which require cutting and polishing.  This inventive polymer-based transmissive medium can be formed using scalable, inexpensive polymer production processes.   Applications: • LiDAR • Electronics • Optics   Advantages: • Inexpensive • Useful for mid- or long-wave IR applications Licensing Manager: Laura Silva LauraS@tla.arizona.edu 520-626-1557