Available Technologies (through the UA Office of Technology Transfer)

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High Resolution and High Throughput Additive Manufacturing

Sat, 2019-03-30 06:11
ua19-090 - Invention: Researchers at the University of Arizona have developed an additive manufacturing system that combines several techniques for high-throughput photopolymerization 3D printing.  The system is capable of printing large complex components with high resolution features at a high speed, and at a lower cost that current micro-scale 3D printing systems.   Background: Over the past few decades, there has been an increasing interest in the fabrication of complex high-resolution 3D parts, using additive manufacturing processes. The known techniques, Stereolithography (SLA), PolyJet Modelling (PJM), and MultiJet Modeling (MJM) can create objects with resolution down to 0.1mm.  This resolution is not sufficient to build high-resolution 3D parts.  The higher resolution techniques of diamond turning, and higher precision types of lithography, are slow and expensive or have difficulty printing complex structures.  There remains a need for an additive manufacturing system that can print large complex structures with high-resolution features.   Applications: Advantages: Licensing Manager: Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-090

Fast Volumetric Imaging of Fluorescent Tissue Structures and Activities

Sat, 2019-03-30 06:11
ua19-101 - Invention: Researchers at the University of Arizona have developed a novel microscope imaging technique that generates high-resolution large-volume 3D images of tissue at subcellular resolution, and captures transient activities within the volume at 100 volume frames per second (vps).  The invention breaks away from the traditional plane-scanning approach and implements volumetric projection imaging instead. Background: In order to study complex dynamics of tissue in live animals, ideally the microscope needs to maintain the sub-micron resolution in deep tissue to resolve activities in subcellular structures, cover a large volume to analyze complex networks, and refresh the volumetric image at high speed to capture transient dynamics.  However, despite many processes, at present there are no known microscopic techniques that fully satisfy the need for resolution, penetration, volume and speed.   Applications: •       Fast 3D subcellular imaging for organs, tissues, and other body parts Advantages: •       Intrinsic high 3D resolution •       Simplified image processing •       Faster frame rates; can accommodate movement in sample •       Large image area/field of view •       Twice the photon sensitivity for increased photon efficiency   Contact:  Amy Phillips AmyP@tla.arizona.edu Refer to case number UA19-101  

Quantitative Large Area Binding Sensor for Detecting Biomarkers

Wed, 2019-03-13 15:32
ua19-049 - Title:  Quantitative Large Area Binding Sensor For Detecting Biomarkers   Invention:  Researchers at the University of Arizona have developed a lens-free holographic microscope (LFHM) for observing and quantifying target biomarkers in a solution, including targets with a large dynamic range in concentration.  LFHM can be used to detect microscale targets (e.g., bacteria and cells) and nanoscale targets (e.g., viruses, DNA strands, and cancer biomarkers).   Advantages: *  can image a large range of target sizes *  accommodates a large dynamic range in concentration *  has a large field of view   Applications: *  cancer biomarker detection   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-049

Phase Unwrapping by Neural Network

Wed, 2019-03-13 15:32
ua19-061 - Title:  Phase Unwrapping By Neural Network   Invention:  This document in-part describes systems and methods that can be used to facilitate reliable and accurate phase unwrapping. The techniques that can be implemented to obtain unwrapped phase using segmentation approaches.  The techniques are also robust against noises in the input data, thereby providing fast and reliable unwrapped phase results.   Background:  Phase unwrapping is an important step in interferometry to remove the ambiguity in the interferograms to obtain the correct phase.  Fringe projection techniques are a commonly used three-dimensional (3D) measurement method for non-specular surfaces, by projecting a series of fringes on the object surfaces.  Phase can be obtained from a series of deformed fringes. Phase unwrapping is needed to process  the wrapped phase in order to reconstruct object surface.  Conventional phase unwrapping approaches are time-consuming and noise sensitive.    Advantages: *  Fast and reliable *  Much less sensitive to noise   Application: *  Wavefront sensing *  Optical metrology   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-061

Microcavity Surface Bioconjugation Using Unilamellar Lipid Membranes for Label Free, Ultrasensitive Detection of Alzheimer's Biomarkers

Wed, 2019-03-13 15:32
ua19-073 - Title:  Microcavity Surface Bioconjugation Using Unilamellar Lipid Membranes   Invention: The present invention outlines a new way of preparing a microtoroid optical resonator for the purpose of detecting amyloid-β plaque. Traditional ways of surface functionalization leave roughness on the optical resonator, making it difficult to achieve a higher q-factor. The present invention provides a new way of smoothing the surface of a resonator so that ultrasensitive detection can be achieved, providing high q-factors as well as reduced scattering loss which is important when detecting key biomarkers such as amyloid-β.   Background: Optical resonators are a key component of biosensors that are used in many different applications. However, the resonator has to have a smooth surface to allow the capture of light at different wavelengths. The ability of a resonator to capture light effectively is referred to as its q-factor (quality factor). Traditional ways of smoothing the surface of a resonator still leave too much residual roughness that leads to a lower q-factor, and thus less accurate detection of biomarkers. Applications: *  Biomarker detection for healthcare diagnostics and drug development *  Defense/security applications to detect explosives, chemical weapons, drugs *  Environmental biosensors for air/water quality *  Detection of disease in agricultural/food products Advantages: *  Achieves better surface smoothness for an optical resonator *  Better q-factor, longer wavelengths *  Better for the detection of biomarkers *  Validated in Alzheimer use case Contact:  Amy Phillips amy_p@tla.arizona.edu Refer to case number UA19-073  

Integrated Frequency Locked Optical Whispering Evanescent Resonator (Flower) Based on Raspberry Pi

Wed, 2019-03-13 15:32
ua19-084 - Invention: Raspberry Pi is a card-sized mini-computer that acts as a data processing center that replaces the prior commercial frequency locking system. It greatly reduces the size and the weight of the FLOWER system, making it possible for the FLOWER system to be carried by people or mounted on a drone.   Background: FLOWER (frequency locked optical whispering evanescent resonator) is a currently patented system (9,739,770B2) which can measure low concentrations of biological and chemical molecules down to the single molecule limit.  Although FLOWER is able to sense low concentrations of molecules, it occupies a large footprint and currently fits on a 4’ x 6’ optical table in the lab. We are interested in miniaturizing FLOWER and making it light weight and portable.    Applications: *  An instrument to detect individual biomedical nanoparticles *  Remotes sensing capabilities   Advantages: •       More portable •       Higher processing capability •       Ability to connect to the internet •       Ability to share data •       Cheaper Licensing Manager: Amy Phillips AmyP@tla.arizona.edu Refer to case number UA19-084  

Virtual Deflectometry Enclosure Screen

Wed, 2019-03-13 15:32
ua19-136 - Title:  Virtual Deflectometry Enclosure Screen   Invention:  This inventions addresses the above shortcomings of existing deflectometry systems and provide s simple and compact, yet accurate, deflectometry devices, methods and systems that can be feasibly implemented for measuring optical components having arbitrary shapes and surface characteristics, including flat and/or highly convex optical components.  The disclosed techniques can enable a 2π-steradian measurement range (i.e., a half-sphere) and a 4π-steradian measurement range.   Background:  Deflectometry is a non-null test method which has been shown to provide surface metrology accuracy similar to commercial interferometry systems.  While existing interferometric and deflectometry techniques may be feasibly implemented for measuring concave and/or small objects, they become prohibitively expensive and even impossible for convex optics, both standard in shape, as well as freeform.  Interferometric approaches, swing arm profilometry, and the Hindle test, for example, typically require measuring sub-apertures of the unit, which are then ‘stitched’ together.  However, having an interferometric setup and the required null optic is not always a viable option.   Advantages: *  Easy to construct *  Measures surface profiles for flats, concave, freeform, and highly convex surfaces *  Can achieve 2pi and 4pi steradian coverage   Applications: * Optical metrology   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number U19-136

Noninvasive Real-Time Patient-Specific Assessment of Stroke Severity

Tue, 2019-01-15 18:56
ua18-140 - Tech ID: 18-140   Title: Noninvasive Real-Time Patient-Specific Assessment of Stroke Severity Invention: The proposed technology is a sensor and software that incorporates patient-specific information and machine learning algorithms to produce a highly biofidelic predictor for tissue infarction after a stroke or transient ischemic attack. Background: Current technology for post stroke and transient ischemic attack is invasive and exposes patients to a high amount of radiation and lack accuracy. The proposed technology focuses on a system that produces an accurate assessment of a patient’s brain tissue post stroke. The system incorporates CTA images to provide real-time estimates stroke severity and cerebral blood flow.   Applications: • Medical device in hospitals to assess patient’s stroke or transient ischemic attack severity   Advantages: • High-resolution • Efficient • Low cost • Accurate • Noninvasive • Real-time cerebral blood flow   Licensing Manager: Bob Sleeper RobertS@tla.arizona.edu 520-626-4604

Targeted Therapeutic Delivery in Nonalcoholic Steatohepatitis (Nash)

Tue, 2019-01-15 18:56
ua18-112 - Title: Targeted Therapeutic Delivery in Nonalcoholic Steatohepatitis (NASH)   Invention: This technology utilizes selective expression of a cell receptor as a novel diagnostic and pharmacologic pathway in assessing and treating NASH.   Background: Non-acoholic Steatohepatitis (NASH), a type of fatty liver disease, is characterized by large fat deposits within liver tissue that facilitate fibrotic liver damage and inflammation. With estimated 3-12% of adults in the US having NASH, the prevalence and incidence rates of NASH are on the rise. Because not all causes for NASH are known, few treatment options exist. This technology contains information that is vital to the development of new therapeutic medications with high selectivity for patients with NASH. In addition, this technology contains the methodologies to develop diagnostic imaging protocols and diagnostic testing protocols for NASH detection and characterization.   Applications:   Licensing Manager:   Licensing Manager: Kaitlyn Norman-Powers        KaitlynN@tla.arizona.edu (520) 621-9907

Kinematically Engaged Yoke System

Mon, 2018-12-31 12:30
ua19-024 - Title:  Kinematically Engaged Yoke System   Invention:  Researchers at the University of Arizona have designed a paradigm-shifting space telescope technology.  The technology produces ultra-lightweight, transmissive lenses that are fabricated economically in segments.  The novel aspects of the technology facilitate quick assembly with very high precision alignment..   Background:  Improvements in space telescope technology are needed. For example, mirror systems may be heavy, costly, and may comprise transmission loss and reduction in light throughput. Also, segmented mirror system has very sensitive alignment and assembly tolerance, which increases the overall system complexity and budget.   Advantages:  *  quick assembly *  excellent alignment among segments *  lightweight *  very large aperture   Applications: *  space-based astronomy *  ground-based astronomy   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-024

Methods and Apparatus for Confocal Endoscopes

Mon, 2018-12-31 12:30
ua19-046 - Title: Methods and Apparatus for Confocal Endoscopes   Invention: Researchers at the University of Arizona have designed a hyperchromatic objective lens system for use in chromatic confocal microscopy.  Advantageously, the use of fewer components for the objective lens may reduce the cost, size, and complexity of the microscopy optics, which can make the chromatic confocal microscope system suitable for endoscopic devices.   Background: In confocal microscopes and confocal endoscopes, multiple images (e.g., en face images) can be acquired at different imaging depths while axially translating the confocal microscope relative to the specimen. This approach of conducting mechanical axial scanning, however, can have difficulties such as in confocal endoscopic imaging of human internal organs, since 1) implementing a precision translation mechanism is challenging in a small endoscope and 2) tissue movement can hamper accurate placement of the imaging depth. Chromatic confocal microscopy can use longitudinal chromatic aberration of the microscope optics to generate different focal planes for different wavelengths and generate cross-sectional confocal images of the specimen without conducting axial scanning of the objective lens.   Applications: • Confocal Endoscopy • Confocal Laser Endoscopy • Optical biopsies   Advantages: • Fewer parts • Smaller size • Less expensive • Less complex   Contact:  Amy Phillips Amyp@tla.arizona.edu Refer to case number UA19-046

Using Machine Learning to Create High-Efficiency Optical Design Tools

Mon, 2018-12-31 12:30
ua19-048 - Title:  Using Machine Learning to Create High-Efficiency Optical Design Tools   Invention:  Researchers at the University of Arizona have developed systems and techniques that enable a determination of an estimated mapping from the design parameter space to the performance parameter space in real time.   Background:  Optical lens design is the process of designing a lens to meet a set of performance requirements and constraints.  The design process is computationally intensive.  One problem in optical system design is that, although finding a mapping from the design parameter space to the performance parameter space is easy (taking only a single ray trace), given a desired set of performance characteristics, it is extremely complicated to determine the corresponding design parameters.   Advantages: * saves time * increases functionality of design software   Applications: * optical design software   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-048

Trapezoidal Shim for Segmented Optics Assembly

Mon, 2018-12-31 12:30
ua19-053 - Title:  Trapezoidal Shim for Segmented Optics Assembly   Invention:  Researchers at the University of Arizona have designed a paradigm-shifting space telescope technology.  The technology produces ultra-lightweight, transmissive lenses that are fabricated economically in segments.  The novel aspects of the technology facilitate quick assembly with very high precision alignment..   Background:  Improvements in space telescope technology are needed. For example, mirror systems may be heavy, costly, and may comprise transmission loss and reduction in light throughput. Also, segmented mirror system has very sensitive alignment and assembly tolerance, which increases the overall system complexity and budget.   Advantages:  *  quick assembly *  excellent alignment among segments *  lightweight *  very large aperture   Applications: *  space-based astronomy *  ground-based astronomy   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-053

Fast Gamma-Ray Interaction-Position Estimation

Mon, 2018-12-31 12:30
ua19-056 - Title:  Fast gamma-ray interaction-position estimation   Invention:  Researchers at the University of Arizona have developed systems and methods for estimating gamma ray positions that are faster, more accurate, and more computationally and memory-use efficient than known systems and methods used in the medical imaging field.     Background:  Scintillator-based detectors have been extensively used in both clinical and pre-clinical SPECT and PET scanners, due to their relatively low cost, high gamma-ray stopping power and fast timing [1]. Position-estimation algorithms or decoding methods are applied for gamma-ray interaction position localization with signals induced by scintillation photons on light sensors (PMTs, SiPMs, etc.). Many gamma-ray position estimation/decoding algorithms based on reference datasets have been proposed because they provide better positioning capability for gamma-ray interactions especially at detector edges and corners, and also filter out events that Compton scatter and deposit energy in multiple positions in the detector.  But reference-data-based methods need detector calibration to acquire their reference datasets, and the position estimation speed remains relatively slow due to the excessive computations required. Thus, the current need for position estimation is for both high levels of accuracy and efficiency.   Advantages: *  Faster *  More accurate position estimation *  Can be used with detectors with complicated mean-detector-response functions .   Applications: *  gamma ray imaging *  other medical imaging   Contact:  Amy Phillips amyp@tla.arizona.edu Refer to case number UA19-056

Chalcogenide Hybrid Inorganic/Organic Polymers (Chips) Using Cyclic Olefinic Comonomers

Fri, 2018-12-21 11:33
ua19-075 - Title: Novel Polymers for Mid- and Long-Wave Infrared Imaging   Invention:  New polymer compositions that are transmissive for mid-wave infrared (3-5 microns) and long-wave infrared (8-12 microns) sensing and imaging.   Background: Infrared imaging conventionally uses expensive inorganic transmissive materials for lenses, such as chalcogenide glass and amorphous germanium, which require cutting and polishing.  This inventive polymer-based transmissive medium can be formed using scalable, inexpensive polymer production processes.   Applications: • LiDAR • Electronics • Optics   Advantages: • Inexpensive • Useful for mid- or long-wave IR applications Licensing Manager: Laura Silva LauraS@tla.arizona.edu 520-626-1557

Silicone Waveguide for Solar Applications With High Concentration

Wed, 2018-12-19 14:14
ua19-041 - Title: Silicone waveguide for solar applications with high concentration   Invention: Researchers at the University of Arizona have developed low-cost silicone-based optical light guides configured to concentrate sunlight onto photovoltaic cells with above 90% optical efficiency.  The fabrication is inexpensive, affords flexibility, and ease of assembly. Integration of multiple light guides enjoys relaxed alignment tolerances compared to glass.   Background: In solar applications, waveguides and/or lightguides are often used to redirect and spatially concentrate the sunlight onto photovoltaic cell (PV-cells). Glass lightguides can be utilized, but can be expensive and complex to fabricate, expecially when small geometrical features are required.  Assembly of a plurality of glass-based lightguides into a full system is also tedious and complicated.  Polymeric materials can address some of these issues, are well known to have a relatively high level of absorbance in the UV and NIR regions of the solar spectrum, when high transmittance is needed.   Applications: • Solar Applications   Advantages: • Transparent in the 300-1700nm region • UV resistant • Design flexibility • Reduces the cost of manufacturing/mass production • High transmission throughout the solar spectrum • Improved tolerance to misalignment while maintaining over 90% optical efficiency   Licensing Manager: Amy Phillips AmyP@tla.arizona.edu Refer to case number UA19-041  

Silicone Aspherical Lens Array for Concentrating Solar Applications

Wed, 2018-12-19 14:14
ua19-040 - Invention:  Researchers at the University of Arizona have designed a silicone based linear lens array capable of high efficiency and low cost. The lens design produces a higher concentration line than traditional lenses, reduces optical aberrations, and facilitates fabrication. The design also creates greater rigidity, reduces Fresnel reflection loss, and eliminates refractive index changes among elements within a complex lens. Background:  Current sunlight-concentrating optical elements and/or systems suffer from various deficiencies.  For example, mirror-based concentrators require robust and costly mechanical design due to their weight, which increases installation costs.  Optical cylindrical lenses made of glass - while arguably being suited for solar applications requiring small linear light-concentration performance - are difficult and costly to manufacture for mass production. Existing polymer lenses have high absorbance in the UV and NIR portions of the solar spectrum, which drastically limits their use in broad-band solar energy concentrators.   Applications: • Solar concentrators   Advantages: • High transmission efficiency in the solar spectrum • Low manufacturing, assembly, and usage costs • Provides for lightweight optics • Increased rigidity of lens array system • Allows for deposition of anti-reflection coating • Provides for optical bonding means between polymer lens and glass without adhesive • Greater clarity • Excellent chemical resistance • Excellent thermos-mechanical stability • Cost effective fabrication • Higher transmittance of light • Reduced photo degradation • Reduced thermal deformation • Less maintenance and light weight Licensing Manager:  Amy Phillips AmyP@tla.arizona.edu Refer to case number UA19-040

Sucrose-Derived Scaffold for Gd MRI Contrast Agent and Method for Use in Colon Cancer Screening

Wed, 2018-12-19 14:14
ua19-099 - Title: A Novel Gd-Sucrose Scaffold for Oral Administration in MR-Colonography   Invention: This invention is a targeted molecular imaging agent to be used in conjunction with MRI or CT. It is designed especially for the early and specific detection of colorectal cancer. The formulation of this novel contrast agent allows for non-invasive imaging of the entire colon, with excellent soft-tissue contrast.   Background: The key to high survival rates for colorectal cancer is the early detection and staging of the disease. Current methods lack high and specific visualization, or are invasive, which leads to patient noncompliance. Over the last decade, MRI used for staging of rectal cancer has been reported to up or down stage rectal cancer by 20%. New imaging agents therefore have an important role to play in improving patient outcomes.   Applications: • Differentiation of benign and malignant disease • Evaluation of response to chemotherapy/radiation therapy • Selection of a patient-specific cancer therapy   Advantages: • Can detect small or flat polyps • Enhanced spatial resolution • Noninvasive (could improve patient noncompliance)   Licensing Manager: Laura Silva LauraS@tla.arizona.edu 520-626-1557

Hybrid Pyramid-Shack-Hartmann Wavefront Sensor

Mon, 2018-12-17 15:04
ua19-002 - Title: Hybrid Pyramid-Shack-Hartmann Wavefront Sensor   Invention: This invention describes a novel design for a wavefront sensor that provides high sensitivity, wide dynamic range, and linearity.     Background:  Wavefront sensors are at the forefront of the adaptive optics field. An essential element of any adaptive optics system is having an effective wavefront sensor that can identify any aberrations in the optical data collected, but current wavefront sensors have a tradeoff between their properties and none yet allow for all of the ideal properties to be reached.   Applications:   Advantages:   Licensing Manager: Amy Phillips AmyP@tla.arizona.edu

Induction Heating for Forming High-Precision Metal Panels

Mon, 2018-12-17 15:04
ua19-008 - Title: Induction Heating for Forming High-Precision Metal Panels   Invention: Researchers at the University of Arizona have developed a method for slumping metals and doped glasses that provides controlled heating across the entire piece, allowing for the formation of optical quality objects.  The process is about 10 times faster than the conventional kiln method and requires much less energy.   Background: Slumping is a method of forming either glass or metal to the shape of a particular mold. This is typically done in a kiln, but unfortunately, this does not eliminate the risk of uneven heating in a material, which can lead to  imperfect slumping.  In addition, there are intense energy requirements due to the high temperatures needed in the kiln, and the length of time it takes to get uniform heating throughout the material.   Applications:   Advantages:   Licensing Manager: Amy Phillips AmyP@tla.arizona.edu